Products of the acid hydrolysis of 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2<i>H</i>-1,4-benzodiazepin-2-one (oxazepam)

Gasparič, Jiří; Zimák, Jiří; Sedmera, Petr; Breberová, Zdeňka; Volke, Jiří

doi:10.1135/cccc19792243

CCCC > Archive > 1979, Volume 44 > Issue 7 > p. 2243

Products of the acid hydrolysis of 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one (oxazepam)

Jiří Gasparič^a, Jiří Zimák^a, Petr Sedmera^b, Zdeňka Breberová^a and Jiří Volke^c

^a Faculty of Pharmacy, Charles University, 501 65 Hradec Králové
^b Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20 Prague 4
^c The J. Heyrovský Institute of Physical Chemistry and Electrochemistry, Czechoslovak Academy of Sciences, 121 38 Prague 2

Abstract

The acid hydrolysis of oxazepam (Ib) was studied. Under various reaction conditions 6-chloro-4-phenylquinazoline-2-carbaldehyde (V) and the compounds VI and VIII were identified among the products besides the expected 2-amino-5-chlorobenzophenone (IVb).

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Products of the acid hydrolysis of 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one (oxazepam)

Abstract