Collect. Czech. Chem. Commun.
1980, 45, 755-760
https://doi.org/10.1135/cccc19800755
Some condensation products of ergoline - I Derivatives with ketones
Jiří Křepelka, Jiří Holubek and Miroslav Semonský
Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
Abstract
Monotopic bis-ergolin-2-yl derivatives of alkanes and cycloalkanes (I-VIII) were prepared on reaction of derivatives of ergoline-I (XI-XIV) with ketones in the presence of sulfuric acid or p-toluenesulfonic acid. Esterification of compound XV with cyclohexanol under catalysis with-p-toluenesulfonic acid gave condensation product IX after previous separation of cyclohexyl ester XVI. The condensation products did not exhibit prolactin inhibiting effect.
