Collect. Czech. Chem. Commun.
1981, 46, 419-427
https://doi.org/10.1135/cccc19810419
Antraquinone-triazine derivatives of polysaccharides. Relation between structure and affinity to lactate dehydrogenase
Peter Gemeiner, Danica Mislovičová, Jiří Zemek and Ľudovít Kuniak
Institute of Chemistry, Slovak Academy of Sciences, 809 33 Bratislava
Abstract
The inhibition effects (I50) of a series of dyes (Cibacrom Blue 3G-A, Procion Blue MX-R, Remazo Brilliant Blue and Ostazin Brilliant Red S5-B) covalently linked to dextran T 70 were the criterion of the relationship between the structure of antraquinone-triazine compounds and their affinity to rabbit muscle lactate dehydrogenase (LDH). The I50 values indicate a substantial importance of the terminal benzenesulfonane moiety in the structure of Cibacron Blue. Also the degree of substitution of polysaccharide plays an important role in the affinity; its influence upon I50 can be expressed for Cibacron Blue-Dextrans T 70 by an equation of line. The influence of the structure of the polysaccharide constituent on the affinity of Cibacron Blue-(α-glucans) towards LDH is discussed, as well.
