Collect. Czech. Chem. Commun.
1981, 46, 1188-1198
https://doi.org/10.1135/cccc19811188
Synthesis of arylthioacetamidoximes as potential antidepressants
Irena Červená, Marta Hrubantová, Marie Bartošová and Miroslav Protiva
Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
Abstract
Reactions of thiophenol and 16 of its derivatives with chloroacetonitrile afforded arylthioacetonitriles IVb-XXb which were treated with hydroxylamine and gave arylthioacetamidoximes IVa-XXa. Compounds VIIa-IXa, XIIa, XVIa and XVIIIa exhibited antireserpine activity in the test of ptosis in mice and compounds IXa and XVIIa in the test of reserpine hypothermia in mice.
