Collect. Czech. Chem. Commun.
1982, 47, 622-624
https://doi.org/10.1135/cccc19820622
Alkylation of ergoline derivatives at position N(1)
Jan Šmidrkal and Miroslav Semonský
Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
Abstract
N(1)-Alkyl-8β-ergolines I-XII were prepared by alkylation of 8β-ergoline derivatives XIII to XVIII with alkyl halides in dimethyl sulphoxide in the presence of potassium hydroxide. The compounds I-XII exhibited weak inhibition effects on the secretion of prolactin
