Collect. Czech. Chem. Commun.
1982, 47, 2448-2453
https://doi.org/10.1135/cccc19822448
Stereospecific total synthesis of (+)-18-methylenevincadifformine
Josef Hájíček and Jan Trojánek
Research Institute for Pharmacy and Biochemistry, 194 04 Prague 9
Abstract
The synthesis and the resolution of (±)-18-methylenevincadifformine (VIII) is described. Its key step is the reaction of methyl 1-methyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-1-carboxylate (XIII) with 2-allyl-5-chloropentanal (XVI).
