Collect. Czech. Chem. Commun. 1986, 51, 684-686
https://doi.org/10.1135/cccc19860684

Asymmetric reduction of p-alkylacetophenones

Otakar Červinkaa, Anna Fábryováa, Ivana Brožováa and Miroslav Holíkb

a Department of Organic Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6
b Lachema, 621 33 Brno

Abstract

Asymmetric reduction of p-alkylacetophenones Ia-VIIa with lithium aluminium hydride in the presence of (-)-quinine affords optically active alcohols Ib-VIIb of the (R)-(+) configuration in optical yields of about 50%.