Collect. Czech. Chem. Commun.
1986, 51, 1133-1139
https://doi.org/10.1135/cccc19861133
The synthesis of substituted 2H-1,2-benzothiazines 1,1-dioxides
Jiří Svoboda, Jaroslav Paleček and Václav Dědek
Department of Organic Chemistry, Institute of Chemical Technology, 166 28 Prague 6
Abstract
The base-catalyzed rearrangement of the esters of 2H-1,2-benzothiazolin-3-one-2-acetate 1,1-dioxide (IIa - IIc) afforded substituted 2H-1,2-benzothiazine-3-carboxylate 1,1-dioxides IIIa -IIIc. After N-alkylation and aminolysis the antiinflammatory drugs piroxicam and isoxicam were obtained.
