Collect. Czech. Chem. Commun. 1988, 53, 2542-2548

Noninvasive continuous monitoring of solid-phase peptide synthesis by acid-base indicator

Viktor Krchňáka, Josef Vágnera, Pavel Šafářb and Michal Leblb

a Léčiva-Pharmaceuticals, 143 10 Prague 4
b Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6


The course and the end point of the acylation of resin-bound amino groups in solid-phase peptide synthesis was monitored by a novel noninvasive qualitative and quantitative test based on the use of the acid-base indicator bromophenol blue.