Collect. Czech. Chem. Commun.
1988, 53, 822-832
https://doi.org/10.1135/cccc19880822
Reaction of 4-substituted benzaldehydes and acetophenones with chloroacetonitrile
Jiří Svoboda, Zuzana Kocfeldová and Jaroslav Paleček
Department of Organic Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6
Abstract
Under conditions of phase-transfer catalysis or in homogeneous solution of potassium tert-butoxide the title compounds give stereoisomeric mixtures of substituted 2,3-epoxy nitriles III and IV. Alkaline hydrolysis of epoxy nitriles IV afforded the corresponding 2-arylpropanals in low yields. On treatment with methanol and potassium carbonate, epoxy nitriles III and IV were converted into epoxy esters in good yields.
