Collect. Czech. Chem. Commun.
1989, 54, 1888-1902
https://doi.org/10.1135/cccc19891888
Synthesis of 2-propynyl ethers of steroid alcohols
Vladimír Pouzara, Lenka Schneiderováb, Pavel Drašara, Oldřich Štroufb and Miroslav Havela
a Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
b Institute of Inorganic Chemistry, Czechoslovak Academy of Sciences, 160 00 Prague 6
Abstract
2-propynyl ethers, derived from steroid alcohols with hydroxyl in position 3β, 17 or 20, were prepared by reaction with propargyl bromide and sodium hydroxide under conditions of phase transfer catalysis. Other hydroxy groups in the steroid molecule were protected with the methoxymethyl or 2-tetrahydropyranyl group.
