Collect. Czech. Chem. Commun.
1989, 54, 2218-2228
https://doi.org/10.1135/cccc19892218
Antiandrogenic A-homo-B,19-dinorandrostanes from 5β-methyl-19-norandrost-9-enes with different substituents in positions 3 and 17
Alexander Kasal
Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6
Abstract
Westphalen-type derivatives II, IV and VIII were converted into derivatives of 4a-methyleno-A-homo-B,19-dinor-5β-androst-9-ene with different substituents in positions 3 and 17 (compounds XII, XIII and XV) which were utilized for the preparation of the antiandrogenic 17β-hydroxy-4aα-methyl-A-homo-B,19-dinor-5β,10α-androstan-3-one (I).
