Collect. Czech. Chem. Commun.
1989, 54, 2240-2247
https://doi.org/10.1135/cccc19892240
Potential antidepressants: 4-(Thioaryloxy)piperidines
Karel Šindelář, Marta Hrubantová, Emil Svátek, Oluše Matoušová, Jiřina Metyšová, Martin Valchář and Miroslav Protiva
Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
Abstract
Nucleophilic substitution reactions of a series of thio-substituted fluoroarenes with 1-methyl-4-piperidinol, 1-benzyl-4-piperidinol, and 1-methyl-4-phenyl-4-piperidinol in the presence of sodium hydride in dimethylformamide gave the title compounds V-XI and XIII. The salts of these bases were pharmacologically tested and salts of compounds V, XI, and XIII showed in behavioural tests properties which are indicative of antidepressant activity.
