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Collect. Czech. Chem. Commun. 1989, 54, 2443-2469
https://doi.org/10.1135/cccc19892443

4H-Benzo[4,5]cyclohepta[1,2-b]thiophenes and 9,10-dihydro derivatives - Sulfonium analogues of pizotifen and ketotifen; Chirality of ketotifen; Synthesis of the 2-bromo derivative of ketotifen

Zdeněk Polívkaa, Miloš Buděšínskýb, Jiří Holubeka, Bohdan Schneidera, Zdeněk Šedivýa, Emil Sváteka, Oluše Matoušováa, Jan Metyša, Martin Valchářa, Radomír Součeka and Miroslav Protivaa

a Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
b Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6

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  • Wenzel Thomas J., Chisholm Cora D.: Using NMR spectroscopic methods to determine enantiomeric purity and assign absolute stereochemistry. Progr Nucl Magn Reson Spectrosc 2011, 59, 1. <https://doi.org/10.1016/j.pnmrs.2010.07.003>
  • Zajac Marián, Hrobárik Peter, Magdolen Peter, Foltínová Pavlína, Zahradník Pavol: Donor–π-acceptor benzothiazole-derived dyes with an extended heteroaryl-containing conjugated system: synthesis, DFT study and antimicrobial activity. Tetrahedron 2008, 64, 10605. <https://doi.org/10.1016/j.tet.2008.08.064>
  • Breyer-Pfaff Ursula, Nill Karl: High-affinity stereoselective reduction of the enantiomers of ketotifen and of ketonic nortriptyline metabolites by aldo–keto reductases from human liver. Biochemical Pharmacology 2000, 59, 249. <https://doi.org/10.1016/S0006-2952(99)00319-6>
  • Tomori Hiroshi, Yoshihara Hisayoshi, Ogura Katsuyuki: Facile Optical Resolution of a Dibenzopyrazinoazepine Derivative and the Nature of Molecular Recognition of Amines by Chiral 2,3-Di-O-(arylcarbonyl)tartaric Acids. Bulletin of the Chemical Society of Japan 1996, 69, 3581. <https://doi.org/10.1246/bcsj.69.3581>
  • POLIVKA Z., BUDESINSKY M., HOLUBEK J., SCHNEIDER B., SEDIVY Z., SVATEK E., MATOUSOVA O., METYS J., VALCHAR M., SOUCEK R., PROTIVA M.: ChemInform Abstract: 4H‐Benzo(4,5)cyclohepta(1,2‐b)thiophenes and 9,10‐Dihydro Derivatives. Sulfonium Analogues of Pizotifen and Ketotifen; Chirality of Ketotifen; Synthesis of the 2‐Bromo Derivative of Ketotifen. ChemInform 1990, 21. <https://doi.org/10.1002/chin.199003169>