Synthesis and <sup>1</sup>H and <sup>13</sup>C NMR spectra of sulfur derivatives of pyrazine derived from amidation product of 2-chloropyrazine and 6-chloro-2-pyrazinecarbonitrile. Tuberculostatic activity

Dlabal, Karel; Palát, Karel; Lyčka, Antonín; Odlerová, Želmíra

doi:10.1135/cccc19902493

CCCC > Archive > 1990, Volume 55 > Issue 10 > p. 2493

Synthesis and ¹H and ¹³C NMR spectra of sulfur derivatives of pyrazine derived from amidation product of 2-chloropyrazine and 6-chloro-2-pyrazinecarbonitrile. Tuberculostatic activity

Karel Dlabal^a, Karel Palát^a, Antonín Lyčka^b and Želmíra Odlerová^c

^a Faculty of Pharmacy, Charles University, 501 65 Hradec Králové
^b Research Institute of Organic Syntheses, 532 18 Pardubice-Rybitví
^c Research Institute of Preventive Medicine, 833 01 Bratislava

Abstract

Homolytic amidations of 2-chloropyrazine and 6-chloropyrazine-2-carbonitrile have been carried out to obtain products which have been used to prepare sulfur derivatives of pyrazine as potential tuberculostatic agents. The ¹H and ¹³C NMR spectra of the products have been measured and interpreted, and the antituberculotic activity has been evaluated.

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Synthesis and 1H and 13C NMR spectra of sulfur derivatives of pyrazine derived from amidation product of 2-chloropyrazine and 6-chloro-2-pyrazinecarbonitrile. Tuberculostatic activity

Abstract

Synthesis and ¹H and ¹³C NMR spectra of sulfur derivatives of pyrazine derived from amidation product of 2-chloropyrazine and 6-chloro-2-pyrazinecarbonitrile. Tuberculostatic activity