Collect. Czech. Chem. Commun.
1990, 55, 1613-1629
https://doi.org/10.1135/cccc19901613
Potential nootropic agents: Synthesis of a series of (2-oxo-1-pyrrolidinyl)acetic acid piperazides
Vladimír Valenta, Karel Šindelář, Jiří Holubek, Miroslav Ryska, Ivan Krejčí, Antonín Dlabač and Miroslav Protiva
Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3
Abstract
The title compounds VI-XXIII were prepared by heating ethyl (2-oxo-1-pyrrolidinyl)acetate (II) with a series of N-monosubstituted piperazines. The propionamides XXVI and XXX were obtained by reactions of the acid chlorides IV and XXXIII with 3-(1-piperazinyl)propionamide. Compounds VI (V⁄FB-13 763) and VIII (V⁄FB-14 745) proved more active than piracetam (I) by their antiamnesic effects in rats, by antagonizing the brain-damaging effects of cycloheximide in infantile rats, and by their potentiation of the effects of anticonvulsant agents.
