Collect. Czech. Chem. Commun. 1995, 60, 216-223
https://doi.org/10.1135/cccc19950216

Conformational Analysis of 2,4-Disubstituted 9-Oxobicyclo[3.3.1]nonane Derivatives

Pelayo Campsa, Joan Castañéb, Carlos Jaimec, Francesc Péreza and Santiago Vázqueza

a Laboratorio de Química Farmaceutica, Facultad de Farmacia, Universidad de Barcelona, Av. Diagonal, s/n; 08028 Barcelona, Spain
b Menadiona, S. A. Palafolls, 08389 Barcelona, Spain
c Unidad de Química Organica, Departamento de Química, Universidad Autonoma de Barcelona, Bellaterra, 08193 Barcelona, Spain

Abstract

The conformational analysis of several 2,4-disubstituted 9-oxobicyclo[3.3.1]nonane derivatives (diesters IIIb and IIIc, and dihalo compounds IV, Va, Vb and VI) derived from 9-oxobicyclo[3.3.1]nonane-exo-2, exo-4-dicarboxylic acid has been studied by 1H and 13C NMR spectroscopy with the aid of Molecular Mechanics Calculations (MM3 program).