Collect. Czech. Chem. Commun.
1995, 60, 1386-1389
https://doi.org/10.1135/cccc19951386
A Facile Synthesis of 6-Cyanopurine Bases
Michal Hocek and Antonín Holý
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic
Abstract
A facile method of preparation of 6-cyanopurine bases from commercially available 6-chloropurines is reported. The 6-chloropurines were selectively protected by THP-functions and the protected derivatives reacted smoothly with tetraethylammonium cyanide and DABCO to give 6-cyanopurine derivatives that were easily deprotected to afford the title compounds.
