Collection of Czechoslovak Chemical Communications - digital archive 

Abstract

Two new benzylisoquinoline alkaloids of the papaverine type, setigerine (racemic α-methoxypapaverine, 1b) and setigeridine (1c), were isolated from Papaver setigerum DC. as the minor constituents. Their structures were established by spectral data and X-ray crystallographic analysis. Papaverine (1a) was isolated as the major alkaloid of the plant (0.05 wt.%) besides of less amounts of morphine, codeine and rhoeadine. In a low yield, protopine, cryptopine, thebaine, rhoeagenine, and N-methylthebainium (as iodide) were obtained and small quantities of laudanosine, stylopine, isoboldine, scoulerine, papaverrubine A, B, C, D and E, coptisine, corytuberine, and magnoflorine were identified by thin layer chromatography.

Keywords: Benzylisoquinoline alkaloids; Setigerine; Setigeridine; Papaveraceae.