Collect. Czech. Chem. Commun. 1996, 61, 1077-1084
https://doi.org/10.1135/cccc19961077

Potential Antagonists of Excitatory Amino Acids and Anticonvulsants: Some Heterocyclic (±)-Pyrrolidine-2-carboxamides

Vladimír Valenta, Karel Dobrovský, Ivan Krejčí and Zdeněk Polívka

Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3, Czech Republic

Individual author index pages


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    1994, Vol. 59, Issue 3, pp. 667–674 [Abstract]
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    1991, Vol. 56, Issue 2, pp. 449–458 [Abstract]
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    1990, Vol. 55, Issue 9, pp. 2304–2316 [Abstract]
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    1990, Vol. 55, Issue 9, pp. 2282–2303 [Abstract]
  • Jiří Jílek, Miroslav Rajšner, Vladimír Valenta, Miloš Borovička, Jiří Holubek, Miroslav Ryska, Emil Svátek, Jan Metyš and Miroslav Protiva
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    1990, Vol. 55, Issue 7, pp. 1828–1853 [Abstract]
  • Vladimír Valenta, Karel Šindelář, Jiří Holubek, Miroslav Ryska, Ivan Krejčí, Antonín Dlabač and Miroslav Protiva
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    1990, Vol. 55, Issue 6, pp. 1613–1629 [Abstract]
  • Vladimír Valenta, Jiří Holubek, Emil Svátek, Oluše Matoušová, Jiřina Metyšová and Miroslav Protiva
    Potential neuroleptics of the orthopramide series; synthesis of heterocyclic 5-amino-2-methoxybenzamides and of some related compounds
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  • Miroslav Protiva, Vladimír Valenta, Zdeňka Kopicová, Juraj Lukáč, Jiří Holubek and Ivan Krejčí
    Potential cerebral stimulants: Esters of 2-dimethylaminoethanol with some lipophilic carboxylic acids
    1990, Vol. 55, Issue 5, pp. 1278–1289 [Abstract]
  • Jiří Urban, Zdeněk Šedivý, Jiří Holubek, Emil Svátek, Miroslav Ryska, Ivan Koruna, Antonín Dlabač, Martin Valchář, Jiřina Metyšová, Zdeněk Polívka, Karel Šindelář, Josef Pomykáček, Marta Hrubantová and Miroslav Protiva
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    1990, Vol. 55, Issue 4, pp. 1067–1076 [Abstract]
  • Miloš Beran, Antonín Černý, Miroslav Kuchař, Hana Adamírová, Jiří Holubek, Jan Taimr, Jaroslav Vachek, Maria Frühaufová, Karel Řežábek, Martin Valchář and Ivan Krejčí
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    1990, Vol. 55, Issue 3, pp. 819–832 [Abstract]
  • Vladimír Valenta, Marie Vlková, Jiří Holubek, Emil Svátek, Jiřina Metyšová and Miroslav Protiva
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    1990, Vol. 55, Issue 3, pp. 797–808 [Abstract]
  • Karel Šindelář, Vladimír Valenta, Jiří Holubek, Oluše Matoušová and Miroslav Protiva
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    1990, Vol. 55, Issue 1, pp. 282–295 [Abstract]
  • Zdeněk Polívka, Miloš Buděšínský, Jiří Holubek, Bohdan Schneider, Zdeněk Šedivý, Emil Svátek, Oluše Matoušová, Jan Metyš, Martin Valchář, Radomír Souček and Miroslav Protiva
    4H-Benzo[4,5]cyclohepta[1,2-b]thiophenes and 9,10-dihydro derivatives - Sulfonium analogues of pizotifen and ketotifen; Chirality of ketotifen; Synthesis of the 2-bromo derivative of ketotifen
    1989, Vol. 54, Issue 9, pp. 2443–2469 [Abstract]
  • Vladimír Valenta, Marie Vlková, Jiří Holubek, Jiřina Metyšová and Miroslav Protiva
    Potential antidepressants: 10-Amino-2-chloro-10,11-dihydrodibenzo[b,f]thiepins
    1989, Vol. 54, Issue 7, pp. 1979–1994 [Abstract]
  • Vladimír Valenta, Marie Vlková and Miroslav Protiva
    Potential neurotropic and antiinflammatory agents: 2-Chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl sulfides
    1989, Vol. 54, Issue 5, pp. 1403–1421 [Abstract]
  • Zdeněk Polívka, Vladimír Valenta, Karel Šindelář, Jiří Holubek, Miloš Buděšínský, Miroslav Ryska, Ivan Koruna, Jitka Kohoutová, Jan Metyš, Jiřina Metyšová, Martin Valchář and Miroslav Protiva
    Potential antidepressants: Saturated side chain amines derived from 6,11-dihydrodibenzo[b,e]thiepin and 4,9-dihydrothieno[2,3-c]-2-benzothiepin
    1989, Vol. 54, Issue 1, pp. 235–247 [Abstract]
  • Hana Hulinská, Zdeněk Polívka, Jiří Jílek, Karel Šindelář, Jiří Holubek, Emil Svátek, Oluše Matoušová, Miloš Buděšínský, Hana Frycová and Miroslav Protiva
    Experimental antiulcer agents: N-substituted 2-(4-methyl-1-piperazinyl)acetamides as pirenzepine models and some related compounds
    1988, Vol. 53, Issue 8, pp. 1820–1844 [Abstract]
  • Zdeněk Polívka, Jan Metyš and Miroslav Protiva
    6,11-Dihydrodibenzo[b,e]thiepin-11-yl 3-quinuclidinyl ethers: New potential intidepressants and antihistamine agents
    1988, Vol. 53, Issue 8, pp. 1806–1811 [Abstract]
  • Zdeněk Polívka, Jiřina Metyšová, Martin Valchář and Miroslav Protiva
    Potential antidepressants: N-phenacyl derivatives of (E)-N-methyl-3-(6,11-dihydrodibenzo[b,e]thiepin-11-ylidene)propylamine
    1988, Vol. 53, Issue 4, pp. 884–888 [Abstract]
  • Vladimír Valenta, Hana Hulinská, Jiří Holubek, Antonín Dlabač, Jan Metyš, Hana Frycová and Miroslav Protiva
    N-substituted derivatives of 6,11-dihydrodibenzo[b,e]thiepin-11-amine and related compounds; Synthesis and pharmacological screening
    1988, Vol. 53, Issue 4, pp. 860–869 [Abstract]
  • Vladimír Valenta, Jiří Holubek, Emil Svátek and Miroslav Protiva
    Synthesis of 4-methoxyphenoxyacetic and 3,4,5-trimethoxyphenoxyacetic acid amides and hydrazides as potential neurotropic and cardiovascular agents
    1987, Vol. 52, Issue 12, pp. 3013–3023 [Abstract]
  • Zdeněk Polívka, Jiří Holubek, Miloš Buděšínský, Oluše Matoušová, Emil Svátek, Jan Metyš and Miroslav Protiva
    Potential antihistamine agents: 4-(6,11-Dihydrodibenzo[b,e]thiepin-11-ylidene)-1-methyltetrahydrothiopyranium iodide and similar sulfonium salts derived from related tricyclic systems
    1987, Vol. 52, Issue 11, pp. 2758–2774 [Abstract]
  • Vladimír Valenta, Jiří Holubek, Emil Svátek, Vladimír Miller, Marie Vlková and Miroslav Protiva
    2-Diethylaminoethyl esters of 1,3-disubstituted propane-2-carboxylic acids
    1987, Vol. 52, Issue 10, pp. 2534–2544 [Abstract]
  • Vladimír Valenta and Miroslav Protiva
    Potential neuroleptics of the orthopramide series; Synthesis of N-substituted 5-(aminosulfonyl)-2-methoxybenzamides
    1987, Vol. 52, Issue 8, pp. 2095–2106 [Abstract]
  • Zdeněk Polívka, Irena Lichá, Petr Taufmann, Emil Svátek, Jiří Holubek and Miroslav Protiva
    Synthesis of 3-(6,11-dihydrodibenzo[b,e]thiepin-11-ylidene)propanoic acid and related compounds
    1987, Vol. 52, Issue 6, pp. 1566–1582 [Abstract]
  • Vladimír Valenta, Jiří Holubek and Miroslav Protiva
    4-Substituted 1-(1-(2-(arylthio)-5-halogenophenyl)ethyl)piperazines; Synthesis and biological screening
    1987, Vol. 52, Issue 4, pp. 1062–1072 [Abstract]
  • Zdeněk Polívka, Jan Metyš and Miroslav Protiva
    Heterocyclic ethers derived from 6,11-dihydrodibenzo[b,e]thiepin-11-ols and 4,9-dihydrothieno[2,3-c]-2-benzothiepin-4-ol; A new series of potential antidepressants and antihistamine agents
    1986, Vol. 51, Issue 9, pp. 2034–2049 [Abstract]
  • Zdeněk Polívka, Jiří Holubek, Emil Svátek, Jan Metyš and Miroslav Protiva
    Synthesis of the semi-rigid analogues of prothiadene and dithiadene as potential antidepressant and antihistamine agents: 11-[2-(Dimethylaminomethyl)cyclohexylidene]-6,11-dihydrodibenzo[b,e]thiepins and 4-[2-(dimethylaminomethyl)cyclohexylidene]-4,9-dihydrothieno-[2,3-c]-2-benzothiepins
    1985, Vol. 50, Issue 5, pp. 1078–1088 [Abstract]
  • Vladimír Valenta, Zdeněk Prošek, Jiřina Metyšová, Martin Valchář, Antonín Dlabač and Miroslav Protiva
    Cataleptic and noncataleptic neuroleptic agents: Synthesis and pharmacology of 4-(2-chloro and 8-chloro substituted 10,11-dihydrodibenzo[b,f]thiepin-10-yl)piperazine-1-ylalkyl ethers and sulfides
    1985, Vol. 50, Issue 5, pp. 1070–1077 [Abstract]
  • Zdeněk Vejdělek, Zdeněk Polívka and Miroslav Protiva
    Synthesis of 7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-1,4-benzodiazepin-2-one
    1985, Vol. 50, Issue 5, pp. 1064–1069 [Abstract]
  • Vladimír Valenta and Miroslav Protiva
    Synthesis of several 4-hydroxy-3,5-dimethoxybenzamides, their O-substituted derivatives and some related compounds as potential neurotropic agents
    1985, Vol. 50, Issue 2, pp. 510–518 [Abstract]
  • Václav Bártl, Karel Šindelář, Vladimír Valenta, Jiří Holubek, Emil Svátek, Jiří Schlanger, Antonín Dlabač, Jiřina Metyšová and Miroslav Protiva
    Potential antipsychotic agents: 2-Chloro- and 2-methyl-11-(2-piperazinoethoxy)-6,11-dihydrodibenzo[b,e]thiepins and some related compounds; Synthesis and pharmacology
    1984, Vol. 49, Issue 11, pp. 2520–2530 [Abstract]
  • Vladimír Valenta, Antonín Dlabač, Martin Valchář and Miroslav Protiva
    α-Benzyldopamine and some related compounds: Synthesis and pharmacological screening
    1984, Vol. 49, Issue 4, pp. 1002–1008 [Abstract]
  • Zdeněk Polívka, Jiří Holubek, Emil Svátek, Jan Metyš and Miroslav Protiva
    Potential hypnotics and anxiolytics: Synthesis of 2-bromo-4-(2-chlorophenyl)-9-[4-(2-methoxyethyl)piperazino]-6H-thieno[3,2,4-triazolo[4,3-a]-1,4-diazepine and of some related compounds
    1984, Vol. 49, Issue 3, pp. 621–636 [Abstract]
  • Zdeněk Polívka, Jiří Jílek, Jiří Holubek, Emil Svátek, Antonín Dlabač, Martin Valchář and Miroslav Protiva
    Noncataleptic neuroleptic agents: 2-Halogeno-8-isopropyl-10-piperazino-10,11-dihydrodibenzo[b,f,]thiepins
    1984, Vol. 49, Issue 1, pp. 86–109 [Abstract]
  • Zdeněk Polívka, Jiří Holubek, Jan Metyš, Zdeněk Šedivý and Miroslav Protiva
    Potential hypnotics and anxiolytics: 8-Chloro-6-(2-chlorophenyl)-1-[4-(2-methoxyethyl)piperazino]-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine and related compounds
    1983, Vol. 48, Issue 12, pp. 3433–3443 [Abstract]
  • Zdeněk Polívka, Martin Valchář and Miroslav Protiva
    Potential noncataleptic neuroleptic agents: Synthesis and pharmacology of 7-chloro-4-[4-(2-hydroxyethyl)piperazino]-4,5-dihydrothieno[2,3-b]-1-benzothiepin
    1983, Vol. 48, Issue 10, pp. 2970–2976 [Abstract]
  • František Brtník, Ivan Krejčí, Běla Kupková, Pavel Hrbas, Jana Škopková, Tomislav Barth and Karel Jošt
    Vasopressin analogues with effect on central nervous system: Synthesis and biological properties
    1983, Vol. 48, Issue 10, pp. 2862–2873 [Abstract]
  • Zdeněk Polívka, Miroslav Ryska, Jiří Holubek, Emil Svátek, Jan Metyš and Miroslav Protiva
    Potential hypnotics and anxiolytics in the 4H-s-triazolo[4,3-a]-1,4-benzodiazepine series: 8-Chloro-6-(2-chlorophenyl)-1-[4-(2-methoxyethyl)piperazino]-4H-s-triazolo[4,3-a]-1,4-benzodiazepine and some related compounds
    1983, Vol. 48, Issue 8, pp. 2395–2410 [Abstract]
  • Zdeněk Polívka, Jiří Holubek, Emil Svátek, Antonín Dlabač, Dušan Půček, Zdeněk Šedivý and Miroslav Protiva
    3-(4-Methylpiperazino)dibenzo[b,f]-1,2,4-triazolo[4,3-d]-1,4-thiazepine and its 6-chloro and 12-chloro derivatives; Synthesis and pharmacology
    1983, Vol. 48, Issue 5, pp. 1465–1476 [Abstract]
  • Vladimír Valenta, Jiří Holubek, Emil Svátek, Antonín Dlabač, Marie Bartošová and Miroslav Protiva
    α-(4-Tolyl)dopamine, derivatives and analogues; Synthesis and pharmacological screening
    1983, Vol. 48, Issue 5, pp. 1447–1464 [Abstract]
  • Vladimír Valenta, Jiří Němec and Miroslav Protiva
    Basic amides of 2,4,5-trichlorophenoxyacetic, 2,4,6-trimethylphenoxyacetic and 4-bromo-3,5-dimethylphenoxyacetic acid and some related compounds; Synthesis and pharmacological screening
    1983, Vol. 48, Issue 4, pp. 1089–1096 [Abstract]
  • Zdeněk Polívka, Miroslav Rajšner, Jan Metyš, Jiří Holubek, Emil Svátek, Miroslav Ryska and Miroslav Protiva
    Antiaminic agents derived from thieno[2,3-c]-2-benzothiepin: 4-(1-Methyl-4-piperidylidene)-4,9-dihydrothieno[2,3-c]-2-benzothiepin and some related compounds
    1983, Vol. 48, Issue 2, pp. 623–641 [Abstract]
  • Miroslav Protiva, Karel Šindelář, Vladimír Valenta, Jiří Holubek, Emil Svátek, Miroslav Ryska, Jiří Schlanger, Jiří Urban and Marta Hrubantová
    Reactions of 11-chloro-11-phenyl-6,11-dihydrodibenzo[b,e]-thiepin with piperidine and some further nucleophiles
    1982, Vol. 47, Issue 11, pp. 3094–3113 [Abstract]
  • Vladimír Valenta, Jan Metyš and Miroslav Protiva
    (6,11-Dihydrodibenzo[b,e]thiepin-11-yl)methylamine, (4-methoxy-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-methylamine and derivatives; Synthesis and pharmacological screening
    1982, Vol. 47, Issue 3, pp. 984–993 [Abstract]
  • Zdeněk Polívka, Jiří Holubek, Emil Svátek, Jiřina Metyšová and Miroslav Protiva
    Fluorinated tricyclic neuroleptics: Synthesis and pharmacology of 2-chloro-8-fluoro-4-(4-methylpiperazino)-4,5-dihydrothieno[2,3-b]-1-benzothiepin
    1981, Vol. 46, Issue 9, pp. 2222–2233 [Abstract]
  • Vladimír Valenta, Marie Bartošová and Miroslav Protiva
    1-[3-(2-Alkoxyphenoxy)-3-phenylpropyl]piperazines and some related compounds
    1981, Vol. 46, Issue 5, pp. 1280–1287 [Abstract]
  • Vladimír Valenta, Antonín Dlabač and Miroslav Protiva
    Potential noncataleptic neuroleptic agents: 2,4-Dichloro- and 2,4,8-trichloro-10-piperazino-10,11-dihydrodibenzo[b,f]thiepins
    1981, Vol. 46, Issue 3, pp. 781–791 [Abstract]
  • Vladimír Valenta, Antonín Dlabač, Marie Bartošová, Emil Svátek and Miroslav Protiva
    10-[4-(3-Hydroxypropyl)piperazino]-8-methylsulfonyl-10,11-dihydrodibenzo[b,f]thiepin and some related potential metabolites of the neuroleptic agents oxyprothepin and methiothepin
    1980, Vol. 45, Issue 2, pp. 529–538 [Abstract]
  • Vladimír Valenta, Marie Bartošová and Miroslav Protiva
    Carbamates and ureas derived from 11-amino-6,11-dihydrodibenzo[b,e]thiepin; Synthesis and pharmacological screening
    1980, Vol. 45, Issue 2, pp. 517–528 [Abstract]
  • Evžen Kasafírek, Vladimír Felt, Ivan Krejčí and Jiří Michalský
    Synthesis of analogues of the thyreotropin releasing factor containing 2-oxoimidazolidine-1-carboxylic acid
    1980, Vol. 45, Issue 2, pp. 452–456 [Abstract]
  • Evžen Kasafírek, Ivan Krejčí and Vladimír Felt
    Synthesis of analogues of the melanocyte-stimulating hormone release-inhibiting factor containing 2-oxoimidazolidine-1-carboxylic acid
    1980, Vol. 45, Issue 1, pp. 294–297 [Abstract]
  • Vladimír Valenta, Emil Svátek, Antonín Dlabač, Marie Bartošová and Miroslav Protiva
    Noncataleptic neuroleptics: Potential metabolites of 2-chloro-10-[4-(2-hydroxyethyl)piperazino]-10,11-dihydrodibenzo[b,fthiepin
    1979, Vol. 44, Issue 10, pp. 3008–3018 [Abstract]
  • Vladimír Valenta, František Kvis, Jiří Němec and Miroslav Protiva
    6,11-Dihydrodibenzo[b,e]thiepin-11-thiol and 11-acetic acid derivatives; Some 2-methyl-6,11-dihydrodibenzo[b,e]thiepins; Synthesis and pharmacological screening
    1979, Vol. 44, Issue 9, pp. 2689–2701 [Abstract]
  • Vladimír Valenta, Jiří Jílek, Josef Pomykáček, Antonín Dlabač, Martin Valchář, Jan Metyš and Miroslav Protiva
    Noncataleptic potential neuroleptics: 2-Methyl-10-(4-methylpiperazino)- and -10-[4-(2-hydroxyethyl)piperazino]-10,11-dihydrodibenzo[b,f]thiepin
    1979, Vol. 44, Issue 9, pp. 2677–2688 [Abstract]
  • Zdenko Procházka, Ivan Krejčí, Běla Kupková, Jiřina Slaninová, Vera Bojanovska, Zdeněk Prusík, Ilse A. Vosekalna, Petr Maloň, Tomislav Barth, Ivo Frič, Karel Bláha and Karel Jošt
    Synthesis and properties of the Nα-glycyl-glycyl-glycyl-8-lysine-vasopressin and its des-glycinamide derivative
    1978, Vol. 43, Issue 5, pp. 1285–1299 [Abstract]