Collect. Czech. Chem. Commun.
1997, 62, 941-947
https://doi.org/10.1135/cccc19970941
Cyclic Dipeptides with 1-Aminocyclopropane-1-carboxylic Acid
Evžen Kasafíreka, Jaroslav Mourala, Jarmila Vinšováb, Antonín Šturca and Jan Taimra
a Research Institute for Pharmacy and Biochemistry, 130 60 Prague 3, Czech Republic
b Department of Organic and Inorganic Chemistry, Faculty of Pharmacy, Charles University,500 05 Hradec Králové, Czech Republic
Abstract
Cyclic dipeptides of the formula cyclo(-Acc-X-), where Acc = 1-aminocyclopropane-1-carboxylic acid, X = Gly, Ala, Val, Leu, Phe or Tyr, were synthesized. The prepared 2,5-piperazinediones showed no proliferative or antiproliferative activity on normal human embryo cells as well as on HL60 leukemia cells. Results of trace memory assays in mice were negative.
Keywords: Dipeptides; 2,5-Piperazinedione derivatives; 1-Aminocyclopropane-1-carboxylic acid.
