Collect. Czech. Chem. Commun.
1998, 63, 115-120
https://doi.org/10.1135/cccc19980115
Crystal Structure of Cyclosporin E
Michal Hušáka, Bohumil Kratochvíla, Martin Buchtab, Ladislav Cvakb and Alexandr Jegorovc
a Department of Solid State Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6, Czech Republic
b Galena Co., R.&D., 747 70 Opava-Komárov, Czech Republic
c Galena Co., Research Unit, Branišovská 31, 370 05 České Budějovice, Czech Republic
Abstract
The structure of cyclosporin E was determined by X-ray diffraction methods and compared with the structure of related cyclosporins. In contrast to cyclosporin A, which crystallizes from acetone as tetragonal dihydrate, cyclosporin E acetone solvate monohydrate (C61H109N11O12·C3H6O·H2O) crystallizes under the same conditions in the monoclinic space group P21 with a = 15.698(2) Å, b = 21.333(3) Å, c = 13.224(2) Å, β = 103.74(1)°, Z = 2, and V = 4 302(1) Å3.
Keywords: Cyclosporin E; Clathrate; Conformation; Crystal structure determination.
