Collect. Czech. Chem. Commun.
1998, 63, 826-834
https://doi.org/10.1135/cccc19980826
Synthesis and Spectral Properties of Methyl 6-Acetyl- or 6-Cyano-3-amino-2-benzoyl-7-furyl-5-methylindolizine-8-carboxylates
Miloslav Chudík, Štefan Marchalín and Katarína Havrilová
Department of Organic Chemistry, Slovak Technical University, Radlinského 9, 812 37 Bratislava, Slovak Republic
Abstract
Good yields of methyl 6-acetyl- or 6-cyano-3-amino-2-benzoyl-5-methyl-7-(5-substituted-2-furyl)indolizine-8-carboxylates (5a-5f) were obtained in the reaction of corresponding 5-acetyl- or 5-cyano-2-formyl-4-(5-substituted-2-furyl)-6-methyl-1,4-dihydropyridine-3-carboxylated (4a-4f) with 3-phenyl-3-oxopropanenitrile. Spectral properties of the indolizines 5 are discussed.
Keywords: 1,4-Dihydropyridines; Indolizines; 2-Formyl-1,4-dihydropyridines; 3-Aminoindolizines; Intramolecular cyclization.
