Collect. Czech. Chem. Commun.
2000, 65, 549-554
https://doi.org/10.1135/cccc20000549
Synthesis and Resolution of a New C2-Symmetric Chiral Bis-Aniline, trans-1,2-Bis(2-aminophenyl)cyclopentane
Jin-Song Yang, Kazuhiro Kondo and Yasuoki Murakami*
School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan
Abstract
New C2-symmetric trans-1,2-bis(2-aminophenyl)cyclopentanes 2a and 2b were synthesized in optically pure forms (99% ee) from the known racemic trans-1,2-bis(2-hydroxyphenyl)cyclopentane (3) by the conversion to its bis-triflate 4 followed by the Buchwald amination and resolution.
Keywords: Amines; Chiral bis-anilines; C2-Symmetry; N-Ligand; Asymmetric catalysis; Axial chirality.
References: 12 live references.
