Collect. Czech. Chem. Commun.
2004, 69, 897-904
https://doi.org/10.1135/cccc20040897
Facile Synthesis of Aryl-Substituted 1,2,5,6-Tetrahydropyrimidines and Their Stereochemical Investigation
Valentin A. Chebanov*, Elena A. Muravyova, Yulia V. Sadchikova, Sergey M. Desenko, Vitaly N. Chernenko, Kiril M. Kobzar and Vladimir I. Musatov
Department of Photoactive Heterocyclic Compounds, Scientific and Technological Corporation "Institute for Single Crystals", National Academy of Science of Ukraine, Lenin Ave. 60, 61001 Kharkiv, Ukraine
Abstract
The present work is devoted to the investigation of 2,4,6-triaryl-1,2,5,6-tetrahydropyrimidine derivatives. A new facile approach to their synthesis based on the reaction of α,β-unsaturated ketones, carbonyl compounds and ammonia was developed. Some stereochemical features of the compounds obtained were fixed on the base of NMR data (including COSY and NOESY experiments).
Keywords: Nitrogen heterocycles; 1,2,5,6-Tetrahydropyrimidines; Multicomponent reactions; Synthetic methods; Structure elucidation; NMR spectroscopy; Chalcones; Pyrimidines; Heterocyclizations.
References: 7 live references.
