Collect. Czech. Chem. Commun. 2005, 70, 1372-1386
https://doi.org/10.1135/cccc20051372

Nucleophilic Substitution and Lipophilicity - Structure Relations in Methylazolopyridazines

Anna Katrusiaka,*, Małgorzata Ratajczak-Sitarzb, Urszula Skierskaa and Wiktoria Zinczenkoa

a Department of Pharmacy, Poznań University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland
b Department of Crystal Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, Poland

Abstract

Syntheses of methyl[1,2,4]triazolo- or methyltetrazolopyridazine isomers, their separation and nucleophilic substitution with morpholine, dimethylamine and hydrazine have been described. The lipophilicity of the azolopyridazines has been measured and related to the number and sites of the methyl substituents. The structures of new methylated azolopyridazines have been characterized by 1H NMR, MS spectra, and X-ray diffraction.

Keywords: Nitrogen heterocycles; Triazolopyridazines; Tetrazolopyridazines; Azolopyridazines; Lipophilicity; X-Ray diffraction.

References: 19 live references.