Collect. Czech. Chem. Commun. 2007, 72, 1398-1406
https://doi.org/10.1135/cccc20071398

Electrode Reaction of Adriamycin Interpreted as Two Consecutive Electron Transfers with Stabilization of the Intermediate

Šebojka Komorsky-Lovrić* and Milivoj Lovrić

Department for Marine and Environmental Research, "Ruđer Bošković" Institute, P.O. Box 180, 10002 Zagreb, Croatia

Abstract

In cyclic voltammetry of adriamycin (doxorubicin hydrochloride) adsorbed on graphite electrode surface, the response of quinone/hydroquinone redox centers is split into two pairs of peaks because of inactivation of semiquinone intermediates by the hydrogen bonds.

Keywords: Adriamycin; Doxorubicin; Surface ECE mechanism; Quinone/hydroquinone redox couple; Cyclic voltammetry; Graphite electrode; Electroreduction; Electrochemistry.

References: 39 live references.