Collect. Czech. Chem. Commun.
2011, 76, 423-442
https://doi.org/10.1135/cccc2011041
Published online 2011-04-13 11:19:05
Electrochemical behavior of Moclobemide at mercury and glassy carbon electrodes and voltammetric methods for its determination
Deniz Altinöz Erdogana, Ibrahim Hüdai Taşdemirb, Nevin Erkc and Esma Kiliça,*
a Ankara University, Faculty of Science, Department of Chemistry, Ankara 06100, Turkey
b Ahi Evran University, Faculty of Arts and Science, Department of Chemistry, Kirşehir 40100, Turkey
c Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara 06100, Turkey
Abstract
Electrochemical oxidation and reduction properties of Moclobemide (MCB) were investigated at glassy carbon electrode (GCE) and hanging mercury drop electrode (HMDE). Diffusion-adsorption behavior and some extra electrochemical parameters such as diffusion coefficient, number of transferred electrons and proton participated to its electrode mechanisms on both electrode and surface coverage coefficient were calculated from the results of cyclic voltammetry and square-wave voltammetry. Reversible catalytic hydrogen wave mechanism was proposed at HMDE and single two-electron/two-proton irreversible oxidation mechanism controlled by adsorption with some diffusion contribution at GCE was proposed. Experimental parameters were optimized to develop new, accurate, rapid, selective and simple voltammetric methods for direct determination of MCB in pharmaceutical dosage forms and spiked human serum samples without time-consuming steps prior to drug assay. In these methods, the lowest limit of detection (LLOD) was found to be 0.0235 μM. Methods were successfully applied to determine the MCB content of commercial pharmaceutical preparations and spiked human urine. The methods were found to be highly accurate and precise.
Keywords: Cyclic voltammetry; Electrochemistry; Electron transfer; Stripping voltammetry; Moclobemide.
References: 22 live references.
