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2002, Volume 5, Collection Symposium Series

ISBN	80-86241-16-5

Conference

Title	XIIth Symposium on Chemistry of Nucleic Acid Components
Location	Špindlerův Mlýn
Date	3 Sep 2002 – 8 Sep 2002

Articles

• pp. 1-15
  Frank Seela Base-modified nucleosides and oligonucleotides: Synthesis and application
• pp. 16-26
  Anna Szmanda, Maria Markiewicz, Przemysław Godzina and Wojciech T. Markiewicz Polyaminooligonucleotides and their combinatorial libraries
• pp. 27-35
  Antonín Holý Synthetic approaches to "opened-ring" acyclic nucleoside phosphonates – novel type of antivirals
• pp. 36-37
  Michal Hocek, Dalimil Dvořák and Martina Havelková Covalently linked purine dimers or trimers and purine–pyrimidine conjugates – analogues of nucleobase-pairs or triplets
• pp. 38-39
  Miroslav Otmar, Milena Masojídková, Ivan Votruba and Antonín Holý Synthesis and cytostatic activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds
• pp. 40-42
  Tomáš Tobrman and Dalimil Dvořák (Purine-6-yl)magnesium chloride: Preparation and reactivity
• pp. 43-47
  Alexander V. Ivanov, Maxim V. Jasko, Yuri S. Skoblov and Marina K. Kukhanova The synthesis of an acyclic nucleotide analogue, (E)-9-(3-phosphonylmethoxypropen-1-yl)adenine
• pp. 48-75
  Kyoichi A. Watanabe Wandering into nucleic acids chemistry: From simple curiosity to useful inventions
• pp. 76-80
  Tomasz Goslinski and Bozenna Golankiewicz Reactions of acyclovir and ganciclovir with α,ω-dibromoalkanes
• pp. 81-86
  Tommy Johansson and Jacek Stawinski Studies on the synthesis of picolylphosphonate diesters
• pp. 87-92
  Johan Nilsson and Jacek Stawinski Oxidative coupling of H-phosphonate and H-phosphonothioate diesters. Iodine as a reagent and a catalyst
• pp. 93-98
  Anastasiya L. Khandazhinskaya, Elena A. Shirokova, Maxim V. Jasko, Dmitry V. Yanvarev, Alexander V. Ivanov, Tatyana R. Pronayeva, Nina V. Fedyuk, Andrey G. Pokrovsky and Marina K. Kukhanova New phosphonoformate and phosphonoacetate prodrugs of AZT and d4T
• pp. 99-120
  Parag Acharya, Johan Issakson, P. I. Pradeepkumar and Jyoti Chattopadhyaya Experimental evidences unequivocally prove the role of stereoelectronics as one of the major forces responsible for the self-assembly of DNA and RNA
• pp. 121-128
  Satu Mikkola, Ulla Kaukinen, Izabella Zagorowska and Harri Lönnberg The cleavage of RNA phosphodiester bonds by metal ions
• pp. 129-134
  Erkki J. Nurminen, Jorma K. Mattinen and Harri Lönnberg Protolytic and nucleophilic role of phosphoramidite method promoters
• pp. 135-144
  V. A. Efimov and O. G. Chakhmakhcheva Phosphono-PNAs: Synthesis, properties and applications
• pp. 145-149
  Tatiana S. Oretskaya, Timofei S. Zatsepin, Evgeny M. Zubin, Anna V. Kachalova, Elena A. Romanova, Dmitry A. Stetsenko and Michael J. Gait Synthesis of 2'-modified oligonucleotides and their conjugates
• pp. 150-153
  Jerzy Boryski and Grzegorz Framski Kinetic and thermodynamic products in glycosylation of adenine
• pp. 154-158
  Janusz Stępiński, Jacek Jemielity, Magdalena Lewdorowicz, Marzena Jankowska-Anyszka and Edward Darżynkiewicz Catalytic efficiency of divalent metal salts in dinucleoside 5',5'-triphosphate bond formation
• pp. 159-168
  Jacek Jemielity, Joanna Zuberek, Janusz Stępiński, Magdalena Lewdorowicz, Anna Niedzwiecka, Dorota Haber, Fowler Tolvert, Ryszard Stolarski, Robert E. Rhoads and Edward Darżynkiewicz Synthesis, physico-chemical and biochemical properties of the novel tri-, tetra- and pentaphosphate mRNA cap analogues
• pp. 169-180
  Barbara Ramsay Shaw, Jing Wan, Xin Wang, Mikhail Dobrikov, Kaizhang He, Kenneth Porter, Jin-Lai Lin, Vladimir Rait, Dmitri Sergueev and Zinaida A. Sergueeva Reading and writing genetic information with boranophosphate (borane phosphate) mimics of nucleotides, DNA, and RNA
• pp. 181-194
  Sergey N. Mikhailov and Ekaterina V. Efimtseva Disaccharide nucleosides and oligonucleotides on their basis
• pp. 195-199
  Ekaterina V. Efimtseva, Sergey N. Mikhailov, Jef Rozenski, Roger Busson, Arthur Van Aerschot and Piet Herdewijn Protection of 1-methyladenosine and its chemical incorporation into oligonucleotides
• pp. 200-207
  Ivan Rosenberg, Magdalena Endová-Petrová, Šárka Králíková, Radek Liboska, Dominik Rejman and Zdeněk Točík From nucleoside phosphonic acids to modified oligonucleotides
• pp. 208-214
  Zdeněk Točík, Radek Liboska, Ivan Barvík, Jr., Miloš Buděšínský, Milena Masojídková, Ivana Kavenová and Ivan Rosenberg Isosteric phosphonate mono- and oligonucleotides originating from 4',5'-didehydronucleoside precursors: Some synthetic possibilities and limitations
• pp. 215-220
  Victoria H. Harris, Clifford Smith, Jonathan Cummins, Alan Hamilton, David P. Hornby and David M. Williams DNA replication with the mutagenic nucleotide dPTP; effects of tautomerism on nucleotide incorporation
• pp. 221-224
  John A. Brazier and David M. Williams Synthesis and applications of C5-amino modified 2'-deoxyuridines
• pp. 225-229
  Stefan Amberg and Joachim W. Engels Synthesis, properties and determination of the configuration of arylpropyl backbone modified oligodeoxynucleotides
• pp. 230-230
  Hans-Joachim Fritz Mechanistic and evolutionary aspects of DNA-uracil glycosylases
• pp. 231-240
  Svetomir B. Tzokov, Isabel K. Macdonald, Iain A. Murray and Jane A. Grasby Investigating catalytic RNA molecules
• pp. 241-244
  Andrew J. Marsh, Claire Price and Jane A. Grasby Synthesis of polyamine–uridine conjugates by derivatisation at the 5-position
• pp. 245-250
  Joachim W. Engels, Thomas J. Lehmann, Jörg Parsch and Thorsten Strube Fluorine substituted DNA and RNA
• pp. 251-255
  Rüdiger Welz and Sabine Müller Polyamine dependent RNA cleavage: Investigations on the function of spermine in hairpin ribozyme catalysis
• pp. 256-260
  Jeremy L. Clark, Steven E. Patterson, J. Christian Mason, Michael J. Otto, Raymond F. Schinazi, Kyoichi A. Watanabe, Dipesh Risal, Barry M. Goldstein and Krzysztof W. Pankiewicz Novel inhibitors of inosine monophosphate dehydrogenase (IMPDH)
• pp. 261-266
  David F. Ewing, Virginie Glacon, Grahame Mackenzie, Denis Postel and Christophe Len Acyclic nucleoside analogues related to d4T and acyclovir – synthesis and conformation
• pp. 267-271
  Philippe Van Rompaey, Kenneth A. Jacobson, Zhan-Guo Gao, Aishe Chen, Dov Barak, Soon-Ai Kim, Kyeong Lee, Andreas Link, Bruce T. Liang, Piet Herdewijn and Serge Van Calenbergh Amine-modified nucleosides as adenosine A₃ neoceptor ligands
• pp. 272-282
  Jacek Stawinski and Adam Kraszewski H-Phosphonates – chemistry and applications
• pp. 283-289
  Michał Sobkowski, Jacek Cieślak, Jadwiga Jankowska, Jacek Stawinski and Adam Kraszewski Dinucleoside aryl phosphorothioates as building blocks for large scale synthesis of chimeric oligonucleotide analogues
• pp. 290-294
  Martin Kullberg, Martin Bollmark and Jacek Stawinski Triphenyl phosphoroselenoate – a new selenizing agent for P(III) compounds
• pp. 295-298
  Ludmila A. Alexandrova, Tatiana N. Ilyicheva, Nina V. Fedyuk, Inna L. Karpenko and Andrey G. Pokrovsky 4'-Thio-5-ethyl-2'-deoxyuridine 5'-phosphonates: Synthesis and antiviral properties
• pp. 299-303
  Eckhard Birch-Hirschfeld, Renate Egerer, Hans-Martin Striebel and Axel Stelzner New ways to immobilize oligonucleotides on DNA-chips
• pp. 304-305
  Petr Čapek, Miroslav Otmar, Milena Masojídková and Antonín Holý Cross-coupling reactions of 2,6-dichloro-9-deazapurine
• pp. 306-307
  Michal Česnek, Antonín Holý and Milena Masojídková Isomeric guanidinopurine nucleosides and their analogues
• pp. 308-311
  V. A. Efimov, O. G. Chakhmakhcheva, M. V. Choob and D. Archdeacon Using chimeric DNA/RNA molecular beacons for target-specific signal amplification
• pp. 312-315
  Irina V. Gulyaeva, Ekaterina V. Efimtseva, Andrei A. Rodionov, Boris S. Ermolinsky and Sergey N. Mikhailov Direct synthesis of 5'-nucleotides using glycosylation reaction
• pp. 316-318
  Virginie Glacon, David F. Ewing, Grahame Mackenzie, Denis Postel and Christophe Len A novel class of unsaturated acyclic nucleosides and the first synthesis of d4T by ring closure metathesis
• pp. 319-323
  Frank Seela and Yang He Oligonucleotides incorporating 6-aza-2'-deoxyisocytidine: Harmonization of the base pair stability in parallel DNA and exonuclease resistance
• pp. 324-325
  Michal Hocek Synthesis of carba-analogues of myoseverin
• pp. 326-327
  Dana Hocková, Antonín Holý and Milena Masojídková Synthesis of acyclic nucleotide analogues derived from 5-substituted 2,4-diamino-6-hydroxypyrimidines
• pp. 328-331
  Ana R Hornillo Araujo, Dolorès Edmont and David M. Williams Synthesis and applications of a tricyclic analogue of N⁶-methoxy-2,6-diamino-2'-deoxyriboside
• pp. 332-334
  Hubert Hřebabecký, Michal Šála, Milena Masojídková and Antonín Holý Synthesis of racemic 2-hydroxy-4- and 2-hydroxy-5-(hydroxymethyl)cyclohexyl nucleoside analogues
• pp. 335-337
  Kerstin Jahn-Hofmann and Joachim W. Engels A new concept for DNA-arrays
• pp. 338-341
  Frank Seela and Anup M. Jawalekar 4-Nitroindazole: Its ambiguous nature in oligonucleotide base pairing and the influence of the glycosylation position on the duplex stability
• pp. 342-343
  Kaisa Ketomäki and Harri Lönnberg Mixed-phase hybridization of short oligodeoxyribonucleotides on microscopic polymer particles: The effects of various one-base mismatches on the duplex stability
• pp. 344-347
  Anastasiya L. Khandazhinskaya, Maxim V. Jasko, Elena A. Shirokova and Marina K. Kukhanova New substrates of terminal deoxynucleotidyl transferase: Synthesis and biological evaluation
• pp. 348-351
  Astrid E. Klöpffer and Joachim W. Engels Universal fluorinated nucleobases: Their effect on the catalytic activity of ribozymes
• pp. 352-355
  Yana S. Kovacheva, Svetomir B. Tzokov, Iain A. Murray and Jane A. Grasby Kinetic studies of the Neurospora VS ribozyme
• pp. 356-357
  Šárka Králíková, Miloš Buděšínský, Ivana Kavenová and Ivan Rosenberg α-Hydroxyphosphonate oligonucleotides: A striking DNA type?
• pp. 358-360
  Marcela Krečmerová, Miloš Buděšínský and Antonín Holý Synthesis of optically pure N⁶-alkyl derivatives of (2R)-3-(adenin-9-yl)-2-hydroxypropanoic acid and related compounds
• pp. 361-364
  Frank Seela and Rita Kröschel 8-Aza-7-deazaguanine N⁸-(2'-deoxy-β-D-ribonucleoside): Synthesis and base pairing
• pp. 365-366
  Radek Liboska, Miloš Buděšínský, Ivana Kavenová, Ondřej Páv and Ivan Rosenberg Hybridization properties of 4'-branched oligonucleotides
• pp. 367-369
  Maria Markiewicz, Katarzyna Adrych-Rożek and Wojciech T. Markiewicz Synthesis of kinetin 2'-deoxynucleoside and its introduction to oligonucleotides
• pp. 370-372
  Kati Mattila, Tuomas Lönnberg, Mikko Ora, Mikko Oivanen and Harri Lönnberg Synthesis and hydrolytic reactions of an N3'-phosphoramidate analog of uridylyl(3',5')uridine
• pp. 373-375
  Sanna Andersson, Mari Lähde, Satu Mikkola, Gareth Morris, Alicja Stachelska, Satu Valakoski and Nicholas H. Williams Metal ion-promoted hydrolysis of mRNA 5'-cap models
• pp. 376-378
  Teija Niittymäki, Ulla Kaukinen, Pasi Virta and Harri Lönnberg Azacrown tethered oligonucleotides: Potential artificial RNases
• pp. 379-380
  Ondřej Páv, Miloš Buděšínský and Ivan Rosenberg 2'-5' Oligoadenylate analogues with C-phosphonate internucleotide linkage
• pp. 381-382
  Nelly Piton, Frédéric Godde and Joachim W. Engels Determination of RNA tertiary structure by advanced electron paramagnetic resonance spectroscopy (EPR)
• pp. 383-384
  Martina Pressová, Radek Liboska, Miloš Buděšínský, Šárka Králíková, Ivana Kavenová and Ivan Rosenberg Oligomerisation aiming at phosphonate analogues of oligoadenylates
• pp. 385-388
  Alexander Y. Skoblov, Andrey N. Semenyuk and Lubov S. Victorova Substrate properties of nucleoside 5'-triphosphates modified at triphosphate residue as substrates towards HIV reverse transcriptases
• pp. 389-390
  Pavel Turek, Michal Hocek and Martin Kotora [2+2+2]-co-Cyclotrimerization of 6-alkynylpurines with diynes: A method for preparation 6-arylpurines
• pp. 391-392
  Václav Vaněk, Miloš Buděšínský, Ivana Kavenová, Markéta Rinnová and Ivan Rosenberg Isosteric phosphonate-pyrrolidine-based dinucleoside monophosphate analogues
• pp. 393-395
  Philippe Van Rompaey, Vanheusden Veerle, Sylvie Pochet, Hélene Munier-Lehmann, Matheus Froeyen, Piet Herdewijn and Serge Van Calenbergh Thymidine (monophosphate) analogues as Mycobacterium tuberculosis thymidylate kinase inhibitors
• pp. 396-398
  Aleksandra Živković, Jan W. Bats and Joachim W. Engels Crystal structures of fluoro- and chloro-modified benzene-nucleosides
• pp. 399-403
  Joanna Zuberek, Janusz Stępiński, Anna Niedzwiecka, Ryszard Stolarski, Harri Salo, Harri Lönnberg and Edward Darżynkiewicz Synthesis of tetraribonucleotide cap analogue m⁷GpppA^m2'pU^m2'pA^m2' and its interaction with eukaryotic initiation factor eIF4E

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